M.Sc Biotechnology, Osmania University, Hyderabad

Email ID: madhavi.mbiotech@osmania.ac.in

Thesis Title: Characterization of CDKN2BAS gene polymorphism in association with Periodontitis & Coronary Artery Disease.

South Indian population is showing increased incidence rate of periodontal associated CAD has caught our research interest which may assist in improving the oral health especially periodontal infection associated with the cardiovascular system. With inflammation paradigm being considered in the CAD pathogenesis, research has indicated that oral sepsis triggers the release of inflammatory cytokines which enter the systemic circulation and exhibit their pro-inflammatory effects and the involvement of inflammatory cytokines in both the diseases has caught our research interest to know the hereditary reasons behind the problem.

M. Sc. (Biotechnology), C.C.S. University, Meerut

Qualified: TSSET-2017, CSIR-NET-2014, APSET-2014, GATE- 2012, GRE-2010

Email ID: rahilaqureshi@yahoo.com

Thesis Title: Structural and immunological characterization of ser/thr phosphatases from Leishmania donovani.

Visceral leishmaniasis, also known as kala-azar, is a vector borne neglected tropical disease caused by a protozoan parasite of Leishmania donovani complex. Leishmanial parasite enters into human macrophage and subverts immune response to establish infection. Phosphatases plays a pivotal role in various cellular processes including cell cycle events, stress related signaling and immunomodulation. Hence, our research focus onto structural characterization of protein phosphatases of Leishmania donovani and subsequently to explore the immunomodulation imparted by these phosphatases in human macrophages. The study could pave the way towards designing of better therapeutics against this perplexing disease.

M.S (Pharm), NIPER, Mohali

Email ID: mailme.malini5@gmail.com

Thesis Title: “Structural analysis on rationally designed Isoflavonoid derivatives in complex with Human Aldose Reductase”.

Inhibition of Human Aldose Reductase, hAR is one of the major enzymes in cataract treatment. A large variety of structurally diverse compounds have been identified as potent hAR inhibitors. Nevertheless, many of them are lacking specificity and sensitivity towards hAR. In pursuit of better ARIs, we have rationally designed a new class of moieties based on the commercially available inhibitors. Structural analysis of these compounds by using co-crystallization studies will assist in designing a better molecule against aldose reductase.

Qualified: Gate 2013-2015 (AIR-57th Rank), TS-SET/2017

Email ID: kbharathireddy@osmania.ac.in

Thesis Title: Molecular and Biophysical studies on Rice tungro virus capsid and protease proteins.

My work involves molecular and biochemical study on Rice tungro spherical virus protease and capsid proteins (coat proteins CP1, CP2 and CP3). Rice tungro spherical virus is a plant pathogenic virus that causes most important tungro disease in rice plants and also co-infects Rice tungro bacilliform virus (RTBV). The role of viral proteases is found to be crucial in regulating many biological events inside a host cell and the activity of these proteases affects folding process of proteins wherein, the conversion of non-functional proteins to functional proteins ultimately leads to the virus maturation and assembly.

M.Sc Biotechnology, Osmania University, Hyderabad

Qualified: AP SET/ 2012

Email ID: neelima.biotechnology@gmail.com

Thesis Title: Biochemical and biophysical characterization of infectious essential hypothetical protein from Mycobacterium tuberculosis.

Our study aims to identify novel target and inhibitors to combat tuberculosis by virtual screening and biochemical characterization. Mycobrowser database will be screened for essential hypothetical proteins of Mycobacterium tuberculosis that are human non homologs. Functional and structural characterization studies will be carried out for chosen protein that explains its role in metabolic pathway of Mycobacterium. Ultimately novel potential therapeutic lead molecule against M.tuberculosis infection will be designed and characterized.

M.Sc Biotechnology, Osmania University, Hyderabad

Topper of Osmania University in 2016.

Email ID: anjini.akkiraju@osmania.ac.in

Thesis Title: Molecular insights into screening and biological evaluation of potent allosteric inhibitors targeting dengue viral NS2B/NS3 protease to inhibit the dengue viral infection.

Research interest of my study aims to screen and identify the novel allosteric inhibitors targeting Dengue viral infection by virtual screening and biochemical characterizations. Structural characterization of NS2B/NS3 protease will be carried out to explain its role in inhibition of dengue viral infections. This study has chosen to overcome the problem of being serotype specificity to lead molecules. Ultimately, designing of potential novel therapeutic allosteric inhibitors as lead molecules raises an interesting route to avoid serotypic sensitivity of Dengue virus during infections.

M. Sc. (Biotechnology), Mahatma Gandhi University, Nalgonda.

Email ID: janapriya385@gmail.com

Thesis Title: “Molecular and structural insights into Nod factor receptor signaling IN CHICKPEA”

A hallmark trait of chickpea (Cicer arietinum L.), like other legumes, is the capability to convert atmospheric nitrogen into ammonia in symbiotic association with rhizobium. The rhizobial nodule symbiosis is wide spread in the legume family. It is in principle restricted to a single family, and it is a major challenge for future agriculture to transfer this symbiosis to non legumes by using nod factors(Lysin kinase motif), followed by- Expression analysis ,Identification ,Cloning, over expression, biochemical characterization of Putative nod factor receptors and Crystallization in chick pea.

M.E Electronics& Communication Engineering, Osmania University, Hyderabad.

Email ID: bmesanjeev@gmail.com

Thesis Title: Design and Development of Electrochemical Aptasensors for detecting various antibiotics in effluent water and employing biotransformation methodsto detoxifying them.

The proposed Aptasensor is aimed to detect various antibiotics in effluent water with large dynamic range. The sensitivity of the proposed sensor will be at the range of nanograms per milli litre having acceptable reproducibility, specificity and stability with fast response. This low cost biosensor is capable of quantitative detection of various antibiotics. After identification and quantitative detection of the various antibiotics, all of them will be inactivated using biotransformation methods, targeting their individual functional groups. Suitable species like P.veroniietc. will be identified as bioremediation agents for different antibiotics to convert them in to non-toxic or degradable waste.

He is working under DST SERB Project as JRF entitled as on Transient over-expression of human CD-200 gene in Nicotiana model plant and biochemical characterization of purified protein for immunotherapy.

Ph.D (Zoology), Osmania University, M. Sc. Biotechnology.

Email ID: swethanagamalla@gmail.com

Project Title: Quantitative proteomic and genomic analysis reveals crosstalk response of Drought-Sensitive and Drought-Tolerant cotton Varieties Identifies Proteomic and genomic Signatures of Drought Adaptability

Major focus of our work is to study to compare Bt and hybrids variety, to evaluate drought responsive proteins which are up regulate, down regulate and unique ones. Thus, those proteins present in wild one and absent in Bt, due to this they lack drought tolerance. Such approaches have great promise to develop genotypes with agronomically desirable traits through molecular approaches or transgenic to improve cotton yield and fiber quality.

PhD (Chemistry), CSIR-Indian Institute of Chemical Technology (Research work), Osmania University (Degree Award); M.Sc. (Chemistry: Drugs & Pharmaceuticals), JNTU; B.Sc. (Chemistry, Industrial Microbiology & Botany), Osmania University

Email ID:dr.idreesmohammed@yahoo.com

Dr. Idrees Mohammed is an expert in the applications of modern approaches in medicinal chemistry, synthetic organic chemistry and chemical biology toward drug discovery and development. He did his doctoral research as a CSIR-JRF and CSIR-SRF at Dr. D. Subhas Bose lab, CSIR-Indian Institute of Chemical Technology, Hyderabad and was awarded a PhD degree in chemistry by Osmania University, Hyderabad in the year 2009. His PhD work resulted in high-impact international publications in the area of ‘synthesis of privileged structures via carbon-heteroatom bond forming reactions and their applications in diversity-oriented synthesis and novel anticancer compounds’. During 2009-2012, he worked in the area of ‘Inhibition of HIV-1 Vif-APOBEC3G Axis as an anti-HIV strategy’ with the internationally reputed chemical biologist Prof. Tariq M. Rana as a postdoctoral associate at Sanford Burnham Prebys Medical Discovery Institute (SBPMDI), La Jolla, California, USA. He then moved to New York University Abu Dhabi (NYUAD) and worked as postdoctoral associate during 2012-15 at Prof. Timothy M. Dore lab in the area of ‘Inhibition of Ras protein maturation as an anticancer strategy’. During his postdoctoral tenures he worked with multidisciplinary teams and collaborated with highly reputed research teams working at University of California San Diego, University of Massachusetts, Massachusetts Institute of Technology, University of Miami, University of Georgia and University of Minnesota. He attended various international scientific conferences and received two best poster presentation awards. He is also experienced in the utilization of High-Performance Computing (HPC) platform for computer-aided drug designing and data management. He attended various skill development training programs like Nanomaterials and Applications in Biology, Computed-Aided Drug Designing, Patent Law & Practice, Etc.