Post Graduate College of Science OU, Saifabad, a Constituent College of Osmania University, is situated at Masabtank in Hyderabad. It was established in 1951 in the prime locality at the foot hills of Banjara Hills. Originally the college offered only intermediate courses and was situated at Gulbarga of erstwhile Nizam state.
Subsequently it was shifted to the present location. Late Nawab Ali Yavar Jung Bahadur, the then Vice-Chancellor of Osmania University, used his benevolent offices to acquire the present College campus at Saifabad (in the western part of Hyderabad) from the former Government of Hyderabad.